补肾活血汤对慢性心力衰竭患者免疫炎症反应的影响

Effect of Bushen Huoxue Decoction on Immuno-inflammatory Response of Patients with Chronic Heart Failure

目的:观察补肾活血汤对慢性心力衰竭患者(CHF)临床疗效及对免疫炎症反应的影响。方法:将60例患者按随机数字表法分为两组,对照组30例用西医常规治疗,治疗组30例在对照组治疗基础上加服补肾活血汤,每日1剂,疗程14 d。观察两组临床症状积分、左室舒张末内径(LVED),左室射血分数(LVEF),血浆脑钠肽(BNP),肿瘤坏死因子-α(TNF-α),白介素-6(IL-6),长正五聚蛋白3(PTX-3)水平的变化。结果:治疗组临床症状积分改善的总有效率(90%)优于对照组(80%),两组比较差异有统计学意义(P<0.05)。治疗组治疗后[BNP(1 058.72±575.62)ng·L-1,IL-6(6.88±0.91)ng·L-1,TNF-α(251.54±52.72)ng·L-1,PTX-3(3.16±0.60)μg·L-1]均较对照组[(1 542.26±732.18)ng·L-1,(9.63±1.25)ng·L-1,(283.24±48.58)ng·L-1,(3.40±0.56)μg·L-1]明显改善(P<0.05),两组患者LVED,LVEF均较治疗前好转,但差异无统计学意义。结论:补肾活血汤可以显著改善CHF患者心功能,降低TNF-α,IL-6,BNP,PTX-3水平,抑制免疫炎症反应,改善预后。

Objective： This study was conducted to observe the clinical efficacy of Bushen Huoxue decoction on patients with chronic heart failure （CHF）, and its effect on immuno-inflammatory response. Method： In this study, sixty patients were divided into two groups by random number table, with 30 cases in the control group by routine western medicine treatment, while 30 cases in the treatment group treated by the combination of western conventional therapy with Bushen Huoxue decoction, taking a dose once for 14 days. We observed the changes of clinical symptom integrals, left ventricular end diastolic diameter （LVED） , left ventricular ejection fraction （LVEF）, brain natriuretic peptide （BNP）, tumor necrosis factor α （TNF-α）, interleukin-6 （IL-6） and pentraxin-3 （PTX-3） in the two groups. Result： The total effective rate of clinical symptom integrals in the treatment group （90%） was improved better than the control group （80%） （ P 〈 0.05 ）. The level of [BNP （1 058.72±575.62） ng·L^-1,IL-6 （6.88±0.91） ng·L^-1, TNF-α （251.54±52.72） ng·L^-1, PTX-3 （3. 16 ±0.60） μg·L^-1] in treatment group after treatment were improved significantly than the control group [ （1542.26±732.18）ng·L^-1, （9.63±1.25） ng·L^-1], （283.24±48.58） ng·L^-1, （3.40±0.56） μg·L^-1] （P 〈 0.05 ）. The improvements in LVED and LVEF in the both groups were better than those before the treatment, but the difference was not statistically significant. Conclusion： Bushen Huoxue decoction could obviously improve the CHF patient＇s cardiac function, reduce the contents of TNF-α, IL-6, BNP and PTX-3, restrain immuno-inflammatory response and improve prognosis.