胃食管反流病问卷辅助诊断婴幼儿胃食管反流病的初步验证

A preliminary test of gastroesophageal reflux disease questionnaire serving as auxiliary diagnosis of gastroesophageal reflux disease in infants and young children

目的 初步验证胃食管反流病问卷（GERD-Q）在婴幼儿胃食管反流病（GERD）辅助诊断中的价值.方法 2011年1月至2014年2月武汉市妇女儿童医疗保健中心门诊或住院部收治的有疑似GERD症状的婴儿148例、幼儿87例,均完成24 h食管pH值监测或上消化道碘水造影检查,任一项阳性即确定GERD的诊断,纳入GERD组,不符合者即纳入对照组.对所有患儿均完成GERD-Q量表调查.采用SPSS 17.0统计软件,率的比较用χ^2检验,组间评分比较用t检验.结果 1 -11个月婴儿中,GERD组（111例）6个单项症状评分（ISS）均高于对照组（37例）（P＜0.05）,GERD组综合症状评分（CSS）[（131.43±66.56）分]高于对照组[（33.70 ±40.03）分]（t=8.42,P＜0.05）.1-3岁幼儿中,GERD组（55例）6个单项症状ISS均高于对照组（32例）（P＜0.05）,GERD组CSS[（98.58 ±66.75）分]高于对照组[（28.50±35.95）分]（t=5.49,P＜0.05）.结论 年龄特异性GERD-Q对婴幼儿GERD症状筛选具有良好的关联度,适合用于对GERD进行评估.

Objective To preliminarily test the value of gastroesophageal reflux disease questionnaire （GERD-Q） in auxiliary diagnosis of gastroesophageal reflux disease（GERD） in infants and young children.Methods From January 2011 to February 2014,148 infants and 87 young children with suspected GERD symptoms were enrolled in the outpatient and inpatient departments of Wuhan Women and Children＇s Medical Care Center.The diagnosis of GERD were made through 24 h esophageal pH monitoring and upper gastrointestinal hysterosalpingography.Those with any examinations being positive were brought into GERD group,and the others into the control group.All cases had been surveyed with GERD-Q.Using SPSS17.0 statistical software,the ratio was compared with chi-square test,and the difference of the scores between groups with t test.Results In infants （1 to 11 months）,the individual symptom scores （ISS） of the 6 symptoms in the GERD group （n =111） were all higher than those in the control group （37 cases） （P 〈 0.05）,and the composite and symptom scores （CSS） [（131.43 ± 66.56） scores] in the GERD group was higher than that [（33.70 ± 40.03） scores] in the control group （t =8.42,P 〈 0.05）.In young children （1 to 3 years old）,the ISS in the GERD group（55 cases） were all higher than those in the control group（32 cases）,and the CSS[（98.58 ± 66.75） scores] in the GERD group was also higher than that [（28.50 ± 35.95） scores] in the control group（t =5.49,P 〈 0.05）.Conclusions There is a good correlation for age-specific GERD-Q to distinguish GERD symptoms in infants and young children,which is suitable for the assessment of GERD.