阿立哌唑与舒必利治疗以阴性症状为主精神分裂症临床对照观察

Aripiprazole vs Sulpiride in Treatment of Schizophrenia with Negative Symptoms

目的:探讨阿立哌唑治疗以阴性症状为主精神分裂症的疗效与安全性。方法:将80例以阴性症状为主精神分裂症患者随机分入研究组和对照组,每组40例,分别使用阿立哌唑和舒必利治疗12周,用阳性与阴性综合征量表(PANSS)和副反应量表(TESS)评定临床疗效和安全性。结果:1两组治疗后PANSS评分均较治疗前下降(P<0.01或0.05);2同期对照比较,阴性症状和精神病理因子积分在治疗后第4、8、12周末(t=-2.014、-4.359、-6.162,-2.180、-3.042、-6.810;P<0.01或0.05)、总分在第8、12周末(t=-3.235、-6.080,P<0.01),研究组显著低于对照组;但阳性症状因子积分在第8、12周末,研究组显著高于对照组(t=4.630、6.142,P<0.01);3在第12周末,研究组临床疗效优于对照组(Z=-2.112,P=0.035);4不良反应总发生率研究组显著低于对照组(χ2=13.333,P=0.000)。结论:阿立哌唑治疗以阴性症状为主精神分裂症疗效确切,安全性高,优于舒必利。

Objective：To explore the efficacy and safety of aripiprazole in treatment of schizophrenia with negative symptoms. Methods：All 80 patients with negative schizophrenia were randomly assigned to study group and control group, each 40 cases. The patients were treated with aripiprazole or sulpiride re- spectively for 12 weeks. The Positive and Negative Syndrome Scale（PANSS） and Treatment Emergent Side effect Scale （TESS）were used to evaluate the efficacy and adverse effect respectively. Results： ①The scores of PANSS were significantly lower after treatment than those before treatment in the both group. ② Contrast comparing ：in the 4th,8th, 12th weekend after treatment,the scores of PANSS with negative and general mental pathological symptoms factors in the study group were significantly lower than those in the control group（ t =-2. 014,-4. 359 ,-6. 162 ,-2. 180,-3. 042 ,-6. 810;P 〈 0.05 ）. So as the total score of PANSS in the 8th, 12th weekend after treatment（ t = -3. 235,-6. 080 ;P 〈 0.01 ）. But .the scores of PANSS with positive factor in the study group were significantly higher than those in the control group in the 8th, 12th weekend after treatment（ t = 4.630,6. 142;P 〈 0.01 ）. ③The clinical efficacy in the study group in the 12th weekend after treatment was significantly better than that in the control group. ④ The incidence of adverse effect in the study group was significantly lower than that in the control group. Conclusion： Aripiprazole is rather effective and safe in treatment of schizophrenia with negative symptoms. It is much better than sulpiride.