健康人群的颌面部定量感觉研究

Thermal and mechanical quantitative sensory testing( QST) in healthy Chinese: site,gender and age difference

目的探讨中国人群三叉神经和躯干神经的定量感觉在部位、年龄及性别之间的差异。方法选择青年组和中年组健康志愿者各20例,在手背、舌尖、下唇及左右颏部分别测量冷/热感觉阈值(CDT/WDT)、冷/热疼痛阈值(CPT/HPT)、机械感觉阈值(MDT)和机械疼痛阈值(MPT),采用重复设计的方差分析进行数据分析。结果三叉神经分布区域的温度和机械敏感性比手背皮肤高,颏部皮肤的温度敏感性比口内黏膜高;青年组比中年组对温度感觉刺激和机械刺激更为敏感,差异有统计学意义;女性对温度疼痛刺激更为敏感,差异有统计学意义。结论温度和机械定量感觉测试的应用可以更好的理解不同感觉表型背后的机制,并且为对中国人群三叉神经区域感觉异常方面的研究提供一些基本信息。

Objective To establish a thermal and mechanical quantitative sensory testing（ QST） profile at intr-and extra-oral sites and hand and to test the site,gender and age differences in healthy Chinese. Methods Twenty young subjects and twenty aged subjects participated in the study. Cold detection threshold（ CDT）,warm detection threshold（ WDT）,cold pain threshold（ CPT）,heat pain threshold（ HPT）,mechanical detection threshold（ MDT） and mechanical pain threshold（ MPT） were measured at four sites： the surface of left hand（ Hand））,the skin of the mental foramen（ Chin）,the tip of the tongue（ Tongue）,the mucosa of lower lip（ Lip）. Statistical analysis was performed using ANOVA with repeated measures to compare the means within and between groups. The bonferroni tests were used to calculate the post-hoc comparisons. Results A significant site effect was observed for CDT,WDT,MDT,and MPT（ P〈0. 01）.There were significant age differences with significantly lower sensitivity for WDT（ P〈0. 01）,MDT（ P〈0. 01）,MPT（ P〈0. 01） and CDT（ P = 0. 01） in the aged group compared to young group. A significantly higher sensitivity for CPT（ P〈0. 01） and HPT（ P = 0. 03）were detected in women compared to men. Conclusions Application of this thermal and mechanical quantitative sensory testing provides some information for a better understanding of the underlying mechanisms of somatosensory phenotypes and for the better further study of sensory dysfunctions in the intr-and extra oral trigeminal area in healthy human.