CXCL12/CXCR4在腺样囊性癌中的表达及对预后的价值

Expression and the prognosis value of CXCL12/CXCR4 in adenoid cystic carcinoma

目的:探讨CXCL12/CXCR4的表达与腺样囊性癌临床病理特征及预后的关系。方法:采用免疫组织化学SP法检测62例腺样囊性癌病理切片中CXCL12/CXCR4表达情况;Kaplan-Meier法、COX模型分析以上2个因子及临床病理相关指标对ACC患者预后生存时间的影响。结果:CXCL12、CXCR4在ACC组织中的阳性率分别是54.8%(34/62例)、77.42%(48/62例);Kaplan-Meier法结果显示CXCL12、CXCR4阳性组生存时间均较阴性组短(P<0.05);多因素结果分析显示CXCR4的表达、病理类型、临床分期、复发/转移是影响ACC预后的独立危险因素(P<0.05)。结论:CXCR4的表达与ACC的恶性程度有关;CXCR4表达、病理类型、临床分期、复发/转移为预测腺样囊性癌预后的重要指标。

Objective：To investigate the expression of CXCL1 2 and CXCR4 in adenoid cystic carcinoma（ACC）and to explore its re-lationship with clinicopathologic characteristics and prognosis of the patients.Methods：The expression of CXCL1 2 and CXCR4 in af-fected tissue was detected immunohistochemically in 62 cases of ACC.Both of the two factors and clinicalpathology factors were pro-cessed in accordance with the Kaplan-Meier method and the COX regression model.Results：The positive rates of CXCL1 2 and CX-CR4 expression were 54.8%（34/62）and 77.42%（48/62）respectively.Patients with the 2 factor expression had a shorter survival time than those without them（P〈0.05）.Multivariate analysis revealed that CXCR4 expression,clinical stage,histological differentia-tion and metastasis/recurrence were independent risk factors for the prognosis of ACC patients.Conclusion：The expression of CXCR4 may be correlated with the malignancy of ACC.CXCR4 expression,clinical stage,metastasis/recurrence and histological differentia-tion can indicate the prognosis of ACC patients.