万古霉素在肥胖人群与正常人群中药动学参数的系统评价

Pharmacokinetic parameters of vancomycin in obese and normal population:a systematic review

目的:通过Meta分析比较万古霉素在肥胖人群和非肥胖正常人群中的药代动力学特点。方法:在Medline、Sciencedirect、Cochrane、CEPS、CETD、CNKI、万方数据库系统搜索相关文献。采用Rev Man4.2软件对其统计分析。结果:总计5篇研究被纳入分析。Meta结果表明:肥胖人群的万古霉素清除率(clearance,CL),稳态表观分布容积(volume of distribution at steady state,Vdss)比正常人群更高。清除率与理想体质量的比值(clearance/ideal body weight,CL/IBW)以及分布容积与理想体质量的比值(volume of distribution/ideal body weight,Vd/IBW)在肥胖人群中更高。但是,清除率与总体质量的比值(clearance/total body weight,CL/TBW)在2组中没有差异。结论:虽然肥胖人群的万古霉素CL和Vdss比正常人群更高,但是2组中的CL/TBW没有差异。

Objective：To compare the pharmacokinetic characteristics between obese and normal patients. Methods：The databases of Medline,Sciencedirect,Cochrane,CEPS,CETD,CNKI and Wan Fang were systematically searched. Rev Man4.2 was used for meta-analysis. Results：A total of 5 researches were included in the research. Meta analysis showed that vancomycin clearance（CL） and distribution volume at steady state（Vdss）were significantly higher in obese population than in normal population. Obese population had higher CL/IBW and Vd/IBW. However,there was no significant difference in CL/TBW between the two groups. Conclusion：CL and Vdss are significantly higher in obese population,but CL/TBW is similar in the two groups.