肺癌患者血清甲状腺激素的变化及临床意义

Clinical study of the change of thyroid hormone in lung cancer patients

目的:本文旨在探讨肺癌患者血清甲状腺激素的变化,以及其在判断疾病病情和预后方面的意义。方法:采用放射免疫分析检测不同期别、性别、年龄、病理类型的肺癌组及对照组样本的游离甲状腺素(free triiodothyronine,FT4)、游离三碘甲状腺原氨酸(free tri-triiodothyronine,FT3)、促甲状腺素(thyroid stimulating hormone,TSH)水平,并应用SPSS 13.0统计分析软件进行分析。结果:肺癌组FT3较对照组下降,两组间的比较有显著性差异;FT4、TSH略有改变,但差异没有显著性。FT3在不同期别组间有显著性差异,随着病情加重,FT3水平逐渐降低,不同性别、年龄、病理类型的肺癌组FT3的变化无统计学意义。结论:肺癌患者血清甲状腺激素水平发生改变,测定恶性肿瘤患者血清甲状腺激素含量可作为估计病情和判断预后的一项现代医学指标,将有助于晚期癌症患者的预后判断。

Objective： To investigate the change of serum thyroid hormone in lung cancer patients, and the value of disease and prognosis. Methods： Detected free triiodothyronine （ free tri - triiodothyronine, FIB ）, promoting thyroxine （ thyroid stimulating hormone, TSH） by radioimmunoassay in different period, gender, age, pathological stage lung cancer and control. Results： FT3 in the lung cancer group was lower than control group, the comparison between the two groups had significant differences ; FT4 ,TSH changed slightly, but the difference was not statistically significant. FIB in various stages between the two groups had significant differences ,with exacerbations,FT3 levels gradually de- creased, FT3 in the different gender, age, pathological staging of lung cancer group was no significant changes. Con- clusion：The serum thyroid hormone levels change in lung cancer patients, serum thyroid hormone levels can be used to estimates malignancy patient＇s condition and prognosis.