microRNA在结肠癌中的研究进展

Progress in researches on microRNA in colon cancer

结直肠癌(colorectal cancer,CRC)是世界范围内最为常见的恶性肿瘤之一,其发病率和死亡率仅次于肺癌。近年来微小RNA(microRNA,miRNA)与包括结肠癌在内的肿瘤的相关性研究已成为热点。miRNA可成为肠癌早期诊断、早期治疗和预后的标志物及潜在生物治疗靶分子,在大肠癌的诊治中将起重要作用。该文就近年来miRNA在结肠癌研究领域的研究进展予以综述。

Calorectal cancer （CRC） is one of the most common malignant tumor in the world, whose morbidity and mortality just rank second to lung cancer. In recent years the correlation research about miRNA （microRNA） and tumors, including colon cancer, has become a hot spot. The miRNA, as molecular markers and potential biotherapy tar- gets,will play an important role in the early diagnosis, treatment and prognosis of colorectal cancer. Here reviews the recent progress in the field of miRNA in colon cancer.