放射性肺炎相关预测指标的研究进展

Predictive elements correlated with radiation pneumonitis : Research progress

放射性肺损伤(radiation-induced lung toxicity,RILT)是胸部肿瘤患者放射治疗的主要副反应之一,亦是影响放射治疗疗效的主要剂量限制性因素。RILT包括放射性肺炎(radiation pneumonitis,RP)和放射性肺纤维化(radiation fibrosis,RF)。放射性肺炎通常发生于放疗开始后的1-6个月。放射性肺纤维化的发生较缓慢通常为数月到几年之间。本综述就与放射性肺炎有关的临床和剂量学等参数进行分析,旨在提供临床可行的预测指标,以指导肺癌放射治疗计划的制订,减少正常组织的放射性损伤。

Radiation - induced lung toxicity （RILT） is one of the most important dose - limiting complication of tho- racic radiation therapy as well as the leading barrier of the clinical improvement. Characteristic clinical features asso ciated with RILT include radiation pneumonitis （RP） and radiation fibrosis （RF）. RF usually occurs in a period of one to six months after radiotherapy and RP often develops progressively over months to years. This review will focus on the clinical and dosimetric parameters related to the risk of radiation pneumonitis in lung cancer patients, in order to guide the radiotherapy decision for clinicians and reduce the injury of normal tissues.