青年和老年乳腺癌临床病理特征比较

Comparative Study of Clinical and Pathological Characteristics of Breast Cancer of Young and Senior Patients

目的:比较青年(≤35岁)和老年(≥65岁)乳腺癌的临床病理特征及雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)的表达。方法:比较青年乳腺癌患者(≤35岁)57例及老年乳腺癌患者(≥65岁)56例的临床病理特征,采用免疫组织化学法检测两组ER、PR、HER-2的表达。结果:青年组乳腺癌肿瘤直径长,临床分期晚,淋巴结转移率及多中心性乳腺癌所占比例高于老年组,ER、PR阳性表达率低于老年组,差异有统计学意义(P<0.05);两组病理类型、HER-2表达率的差异无统计学意义(P>0.05)。结论:青年乳腺癌较老年浸润性更强、发展更快、恶性程度更高。

Objective： To investigate the clinical and pathological characteristics of breast cancer between young（ ≤35 years old） and senior（ ≥65 years old） patients and expressions of ER,PR and HER-2. Methods： The clinical and pathological characteristics of 57 young patients and 56 senior patients were compared,and the expressions of ER、PR and Her-2 were detected by means of immunohistochemical Envision. Results： The young patients group exhibited longer diameter of tumor,the rates of lymph node metastasis and multicentric breast cancer were higher than senior group,and the positive expression rates of ER and PR were lower than senior group,differences were statistically significant（ P〈0. 05）; concerning pathological type of both groups and expression rate of HER-2,differences had no statistical significance（ P〉0. 05）. Conclusions： Breast cancer in young patients are more invasive,faster and have higher malignant than senior patients.