慢性阻塞性肺疾病患者血清脂联素水平变化及其临床意义

Serum levels of Adiponectin in chronic obstructive pulmonary disease changes and its clinical significance

目的探讨慢性阻塞性肺疾病(COPD)患者血清脂联素水平变化及其临床意义。方法选取符合诊断标准的COPD患者急性加重组、稳定期组及正常对照组各40例,对所有研究对象行肺功能检查,用ELISA法测定血清脂联素水平,并与COPD严重程度进行相关性分析。结果在控制血糖、血脂、年龄、性别及体重指数后,COPD急性加重组、稳定期组患者血清脂联素水平明显高于对照组(P<0.05),COPD急性加重组显著高于稳定期组(P<0.05);COPD急性加重组、稳定期组患者血清脂联素水平与FEV1%预计值均呈负相关(P<0.01)。结论 COPD急性加重组、稳定期组患者血清脂联素水平均升高,脂联素在COPD炎症发生过程中起一定的作用。

Objective To explore the changes and clinical significance of serum levels of Adiponectin（APN）in the patient with chronic obstructive pulmonary disease（COPD）.Methods A total of40 cases of acute exacerbation of COPD（AECOPD group）,40 cases of stable COPD（stable of COPD group）and 40 cases healthy subjects（healthy control group）that conformed to the diagnosis standard of COPD were randomly selected.Pulmonary function tests were performed in all the subjects,then serum levels of APN were measured and analyzed for their correlation with COPD severity.Results After controlling for blood glucose,blood lipid,age,gender and body mass index（BMI）,serum levels of APN both in AECOPD group and stable of COPD group were significantly higher than healthy control group（P〈0.05）;AECOPD group was significantly higher than stable of COPD group（P〈0.05）.Serum levels of APN both in AECOPD group and stable of COPD group were correlated with FEV1%pred negatively（P〈0.01）.Conclusion Serum levels of APN are elevated both in AECOPD group and stable of COPD group.Adiponectin plays a role in the process of inflammation in COPD.