家兔鼻腔给药冰片-羟丙基-β-环糊精包合物的药动学研究

Pharmacokinetics in rabbits blood after intranasal administration of borneolhydroxypropyl-β-cyclodextrin inclusion

目的研究冰片-羟丙基-β-环糊精包合物经鼻腔给药后在兔体内的药动学。方法包合物经鼻腔给药后,采用GC法测定兔血浆中冰片浓度,以DAS 2.1.1软件拟合,计算相关药动学参数。结果冰片-羟丙基-β-环糊精包合物经兔鼻腔给药后的体内过程符合二室模型,Cmax为8.162 mg/L,达峰时间tmax为1 min。结论明确了冰片-羟丙基-β-环糊精包合物经鼻腔给药后在兔体内的药动学特征,为进一步制剂研究提供了参考。

Objective To study the pharmacokinetics in rabbits blood after intranasal administration of bomeol-hydroxypropyl-[3- cyclodextrin inclusion. Methods After intranasal administration, GC method was used to determine contents of borneol in plasma, and the pharmacokinetic parameters were calculated by the software of DAS 2.1.1. Results Pharmacokinetics of bomeol-hydroxypropyl-β-cyclodextrin inclusion in rabbits fitted with the two compartment model, and Cmax was 8.162 mg/L, tmax was 1 min. Conclusion Pharmacokinetic characters ofborneol in rabbits are confirmed which can provide reference for further study of preparation.