紫外分光光度法-核磁共振法用于胆甾类人工受体对酚类的识别研究

Application of UV Spectrophotometry-NMR Methodology in Research on Recognition Properties of Receptors Based on Deoxycholic Acid for Phenolic Compounds

利用常规加热方法,以脱氧胆酸甲酯为主体、芳酰肼及氨基酸甲酯为手臂合成了分子钳a-d.利用紫外分光光度法及1H NMR研究考察了部分分子钳对苯酚、对甲氧基苯酚、间甲氧基苯酚的识别性能,并测定了主客体之间的结合常数(Ka)和自由能变化值(-△G0).研究结果表明,主体分子钳与所考察的酚类化合物可形成1∶1型超分子配合物.

Under the conventional heating condition, molecular tweezers a-d derived from deoxycholic acid were synthesized using deoxycholie acid methyl ester as the spacer, aryl hydrazine and carbamate as arms. Selective recognition properties of these molecular tweezers for phenol, p-methoxyphenol and m-methoxyphenol have been investigated by UV-Vis spectra titration and 1H NMR study. The results indicate this type of molecular tweezers can form 1 ： 1 supramolecular complex with phenol, p- methoxyphenol and m-methoxyphenol. The association constants （Ka） and Gibbs free energy changes （-△G^0 ） for the supramolecular complexes have also been determined.