阿司匹林联合氯吡格雷治疗急性心肌梗死的临床分析

Clinical Analysis of Aspirin Combined with Clopidogrel in the Treatment of Acute Myocardial Infarction

目的：研究分析急性心肌梗死的临床治疗方法。方法：选取我院从2010年12月-2013年12月收治的急性心肌梗死患者120例,按照随机数字法分为观察组和对照组,每组60例;对照组患者给予阿司匹林口服治疗,观察组患者在对照组治疗基础上联合氯吡格雷、肝素治疗;观察对比两组患者住院期间心血管事件发生情况、血管再通率、再闭塞发生率以及左室射血分数（LVEF）情况。结果 ：观察组治疗后再发心肌梗死、梗死后心绞痛、死亡率和再闭塞发生率情况都明显低于对照组,差异具有统计学意义,P〈0.05;两组患者的血管再通率比较差异没有统计学意义,P〉0.05;观察组LVEF明显优于对照组,差异具有统计学意义,P〈0.05。结论：阿司匹林联合氯吡格雷治疗急性心肌梗死具有比较好的治疗效果,能够有效减少心血管事件的发生率,提高患者的生活质量,值得临床推广运用。

Objective： To study and analysis the clinical treatment of acute myocardial infarction. Method： From December 2010 to December 2013, 120 patients with acute myocardial infarction in our hospital were randomly divided into control group and observation group, each group with 60 patients. The control group were treated with oral aspirin therapy, while the observation group were given clopidogrel and heparin plus oral aspirin therapy. To observe the cardiovascular events, the recanalization rate, re occlusion rate and left ventricular ejection fraction （LVEF） condition of the two groups in the hospital. Results： After the treatment, the recurrent myocardial infarction, angina after myocardial infarction, mortality and re occlusion rate of the observation group were significantly lower than the control group, with statistically significant difference, P〈0.05; the difference of recanalization rate between the two groups was not statistically significant, P 〉0.05; in the observation group, LVEF was significantly better than the control group, with statistically significant difference, P〈0.05. Conclusion： Aspirin combined with clopidogrel therapy has good therapeutic effect in patients with acute myocardial infarction, can effectively reduce the incidence of cardiovascular events, improve the quality of life of patients, therefore should be adopted in wider clinical treatment.