细胞因子在脑缺血损伤中的作用研究进展

The Investigative Progression of the Effect of Cytokines on Cerebral Ischemia Injury

脑缺血一旦发生,往往引起不同程度的脑损伤。缺血脑组织会产生一系列复杂的病理生理学改变。一组称为细胞因子的多肽调节物质在脑缺血损伤过程中起着关键的作用。包括神经细胞在内的多种细胞能够产生和分泌细胞因子,它们的表达时相性和作用各不相同。脑缺血引起TNF-α、IL-1、IL-6、IL-8、IL-10和FKN等多种细胞因子的表达和释放,进而触发有关损伤和修复的应答。这些参与脑缺血损伤的细胞因子能通过复杂的细胞因子网络对中枢神经系统发挥着毒性或保护效应。探究它们在脑缺血损伤中的确切作用将有助于神经系统疾病的临床治疗。现对几种关键的细胞因子综述如下。

Once cerebral ischemia happens, it could induce different levels of brain damage frequently. Ischemic brain tissue leads to a series of complex pathophysiological changes. A set of polypeptide cytokines play a capital role in the process of cerebral is- chemia injury. Many kinds of cells can produce and secrete cytokines, including nerve cells. These cytokines have different expressions of phase and effect. Cerebral ischemia causes the expression and release of various cytokines,such as TNF-α, IL-1, IL-6, IL-8, IL-10 and FKN. This event triggers the response concerned with injury and repair. These cytokines, which participate cerebral ischemia injury can reduce toxical or protective effect on central nervous system through a complex network of cytokines. Investigating their definite effect during the progression of cerebral ischemia injury will conduce to the clinical treatment of nervous system diseases. This article reviews the effect of cerebral isehemia injury of several capital cytokines.