胃癌淋巴结微转移的临床研究进展

Advance in Research on the Clinical Significance of Lymph Node Mocrometastasis of Gastric Cancer

胃癌是我国目前最常见的恶性肿瘤之一,微转移是恶性肿瘤在发展过程中所形成的尚处于临床不可探测阶段的微小转移灶,播散并存活于淋巴系统、血液循环、骨髓、肝、肺等组织器官中,是恶性肿瘤复发和转移的根源。目前对胃癌淋巴结微转移的深入研究主要集中在通过寻找不同的检测方法、途径和特异性肿瘤标志物,对常规检查淋巴结为阴性的胃癌,微转移检测可能对准确地确定临床分期、指导治疗、判断预后有积极临床意义。现就胃癌微转移检测研究的现状和存在的问题予以综述。

Gastric cancer is one of the most common malignant tumors. Micrometastases are clinically undetectable occult metastases disseminated to and survived in the lymphatic system, circulation system, bone marrow, liver, lung, and other organs and tissues in the progression of malignancies from which overt metastases and recurrences may eventually generate. Currently, the fu^er investigation of lymph nodes micrometastases on gastric cancer focuses on finding by different detection methods, approaches and specific tumor markers, micrometastasis detection in negative lymph nodes of gastric cancer is recommended to precisely determine the tumor stage, in order to direct cancer therapy and predict prognosis. Here is to give a brief review on the advances and existing problems in detecting micrometastases of gastric carcinoma.