蛋白酪氨酸磷酸酶SHP-2与疾病的相关性研究进展

The Development of Protein-tyrosine Phosphatase SHP-2 and Correlated Diseases

蛋白酪氨酸磷酸酶家族由130多种蛋白酪氨酸磷酸酶组成,它们和蛋白质酪氨酸激酶家族一起调控蛋白质中酪氨酸残基的磷酸化以及去磷酸化的动态平衡,它们的活性直接决定细胞内蛋白质的磷酸化水平的高低。SHP-2是蛋白酪氨酸磷酸酶家族的一员,在各种细胞和组织中均有广泛的表达,参与多个信号传导通路,介导细胞的生长、分化、迁移、粘附及凋亡等。SHP-2的表达异常会导致多种疾病的产生,但是相关综述较少,同时未见文献报道其在胶质瘤中的作用,因此本文简要介绍SHP-2的结构、功能、信号传导,并阐述了SHP-2与常见疾病的关系。

Protein-Tyrosine Phosphatase （PTPs） Family is constructed by more than 130 protein-tyrosine phosphatases, and could work together with protein-tyrosine kinase to modulate of phosphorylation and dephosphorylation balancing of tyrosine residue of proteins. Their activities affect the phosphorylation level of cellular proteins directly. SHP-2 is a member of PTPs Family, expressed extensively in cells and tissues. SHP-2 is involved in several cell signal pathways, as well as inducing cell proliferation, differentiation, migration, adhesion and apoptosis. The abnormality of SHP-2 would result in many disorders and disease, but the related review is is less. At the same time, the literature that reported its role in the glioma has not been found. So this article reviewed the structure, functions, cell signal transduction of SHP-2, as well as the diseases which are induced by SHP-2 dysfunction.