参苓白术散与美沙拉嗪对溃疡性结肠炎患者血清IL-17、IL-23及TNF-α水平的影响

Effects of Shenlingbaizhu Powder and Mesalazine on the IL-17, IL-23 and TNF-α of Patients with Ulcerative Colitis

目的:探讨参苓白术散联合美沙拉嗪治疗脾胃气虚型溃疡性结肠炎的疗效及对血清细胞因子水平的影响。方法:按照随机数字表法将2013年1月至2014年1月我院收治的脾胃气虚型溃疡性结肠炎患者分为两组,对照组给予美沙拉嗪口服治疗,观察组在对照组基础上予参苓白术散口服治疗,比较两组患者的临床疗效及血清细胞因子的水平变化。结果:观察组患者治疗的总有效率优于对照组,差异有统计学意义(P<0.05);治疗后,两组患者Sutherland DAI评分均获得改善,且观察组优于对照组,差异具有统计学意义(P<0.05);两组患者的IL-17、IL-23及TNF-α水平均显著降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。结论:参苓白术散联合美沙拉嗪对脾胃气虚型溃疡性结肠炎具有良好的临床疗效,能够改善患者血清细胞因子的水平。

Objective： To explore the effects of Shenlingbaishu powder combined with salad oxazine on the treatment of ulcerative colitis and its influence on levels of cytokines. Methods： The patients with ulcerative colitis who were treated in our hospital from January 2013 to 2014 were selected and randomly divided into the observation group and the control group. The patients in the observation group were treated by shenlingbaizhu powder combined with mesalazine, while the patients in the control group were treated with the salad oxazine. Then the levels of cytokines in serum of patients were detected and compared between the two groups. Results：The total effective rate of observation group was better than that of the control group with statistically significant difference（P〈0.05）;After the treatment, the Sutherland DAI score of patients in the two groups improved, and the observation group was better than that of the control group with statistically significant difference（P〈0.01）; The expression levels of IL-17, IL-23 and TNF-a reducedand the observation group was lower than those of the control group with statistically significant differences（P〈0.01）. Conclusion： The effect of Shenlingbaizhu powder combined with mesalazine on the treatment of ulcerative colitis could be better with the improvement of the cytokines levels.