摘要
目的:探讨老年社区获得性肺炎患者TNF-α和sTREM-1表达水平及其临床意义。方法:从我院选择48例社区获得性肺炎患者为CAP组(重症组和普通组),另选取对照组48例。收集两组患者的血浆及BALF,分别收集重症组患者住院后1天、4天的血浆和BALF,对比各组sTREM-1和TNF-α的表达水平。结果:对照组TNF-α和sTREM-1的表达水平均低于CAP组(P<0.05);重症患者的TNF-α和sTREM-1表达水平高于普通组和健康对照组(P<0.05)。重症患者TNF-α表达水平与对照组无显著差异(P>0.05),而s TREM-1表达高于对照组,差异有统计学意义(P<0.05)。结论:TNF-α和sTREM-1表达水平与CAP的发病过程密切相关,其表达水平与CAP的严重程度呈正相关。
《Progress in Modern Biomedicine》 2015-09Add to Favorite Get Latest Update Objective： To explore the clinical significance of the expression of TNF- α and STREM-1 in elderly patients with community-acquired pneumonia（CAP）. Methods： 48 CAP patients from Department of Respiratory Medicine in our hospital were enrolled based on the selection criteria and divided into severe group and ordinary group. The plasma and bronchoalveolar lavage fluid（BALF） of CAP group, control group, severe CAP patients＇ first day and fourth day after treatment in hospital were collected. The expression levels of sTREM-1 and TNF-α of each group were compared. Results： TNF-α and STREM-1 levels of control group were lower than those of CAP group with statistically significant differences（P〈0.05）. TNF-α and STREM-1 levels of severe CAP patients were higher than ordinary CAP patients and healthy controls（P〈0.05）. No obvious differences existed between TNF-α level of severe CAP patients and lung cancer controls（P〈0.05）. Significant differences existed between sTREM-1 level of severe CAP patients and lung cancer controls（P〈0.05）. Conclusion： The expression levels of TNF-α and sTREM-1 were associated with pathogenesis and progression and severity of CAP.
出处
《现代生物医学进展》
CAS
2015年第9期1695-1697,共3页
Progress in Modern Biomedicine
基金
国家自然科学基金青年科学基金项目(30901795)
