心理干预联合氟哌噻吨美利曲辛片对老年高血压伴焦虑抑郁患者血压的影响

Effect of Psychological Intervention Combined with Flupentixol and Melitracen Tablets on Blood Pressure of Elderly Hypertensive Patients with Anxiety and Depression

目的:研究心理干预联合氟哌噻吨美利曲辛片对老年高血压伴焦虑抑郁患者的血压影响。方法:选取2013年4月到2014年4月某院收治的老年高血压伴焦虑抑郁的患者110例,按照随机数字表法将患者分为研究组和对照组,每组55例,对照组给予常规降压治疗,研究组在对照组的基础上给予心理干预,同时服用氟哌噻吨美利曲辛片,治疗时间均为8周,应用抑郁自评量表(HAMD)和汉密尔顿焦虑自评量表(HAMA)的评分来评价患者的抑郁状态,比较两组降压疗效、HAMD评分、HAMA评分以及不良反应。结果:研究组降压总有效率94.5%(52/55),对照组降压总有效率为67.3%(37/55),两组比较差异具有统计学意义(x2=12.952,P=0.013);研究组治疗后HAMA评分和HAMD评分分别为(10.5±0.6)分、(11.9±1.1)分显著低于治疗前的(20.8±0.4)分、(31.2±0.7)分,与治疗前比较差异具有统计学意义(t=9.923,10.628,P=0.025,0.019),与对照组比较差异具有统计学意义(t=9.823,11.628,P=0.023,0.016);两组不良反应比较差异无统计学意义(x2=5.492,P=0.072)。结论:心理干预联合氟哌噻吨美利曲辛片治疗老年高血压伴焦虑抑郁者具有较好的降压效果,能改善患者焦虑抑郁状态,且无严重不良反应。

Objective： To study the effect of psychological intervention combined with flupentixol and melitracen tablets on blood pressure of elderly hypertensive patients with anxiety and depression. Methods： 110 cases of elderly patients with hypertension accompanied with anxiety and depression in our hospital from April 2013 to April 2014 were divided into the study group and the control group with 55 cases in each group according to random number table methods, the control group was given conventional therapy while the study group received psychological intervention and took the flupentixol and melitracen tablets on the basis of conventional therapy,all patients received treatment for 8 weeks, the depressive state of patients was evaluated by self rating depression Scale（HAMD） and Hamilton Anxiety Scale（HAMA） score, curative effect, blood pressure, HAMD score, HAMA score and adverse reactions of two groups were compared. Results： The total antihypertensive effective rate of the study group was 94.5%（52/55）, the control group was 67.3%（37/55）, with significant differences between two groups（x2=12.952,P=0.013）; HAMA score and HAMD score of the study group after treatment were（10.5±0.6） points,（11.9±1.1） points, significantly lower than those before treatment（20.8±0.4 points,31.2±0.7 points respectively）, the difference was statistically significant when compared with the control group（t=9.823,11.628, P=0.023,0.016）; There was no statistically significant difference in adverse reactions between two groups（x2=5.492, P=0.072）. Conclusion： The psychological intervention combined with Flupentixol and melitracen tablets have a better antihypertensive effect in treatment of elderly hypertensive patients with anxiety depression, which can improve the anxiety and depression of the patients,without serious adverse reactions.