急性冠脉综合征患者CD4^+T淋巴细胞亚群的变化及临床意义

The Changes and Significance of CD4^+T Lymphocyte Subsets in Patients with Acute Coronary Sydrome

目的:研究急性冠脉综合征(ACS)患者CD4+T淋巴细胞亚群的变化及临床意义。方法:收集2013年3月-2014年3月入住我院首次行冠脉成形术(PCI)治疗的ACS患者88例以及造影结果正常患者28例。分别于冠脉造影时取冠脉血流式细胞技术检测CD4+T细胞亚群Th1/Th2、Th17/Treg比例表达变化。结果:与对照组相比,ACS组患者冠脉血中Th1、Th17细胞占CD4+T淋巴细胞的百分比显著升高,而Th1、Treg细胞占CD4+T淋巴细胞的百分比显著降低,差异具有统计学意义(P<0.05)。结论:ACS患者体内免疫反应增强,CD4+T淋巴细胞不同功能亚群均参与了动脉粥样硬化(AS)的发生发展,Th1、Th17可促进AS的进展和不稳定性,而Th1、Treg作用相反。

Objective： To investigate the changes and significance of CD4＋T lymphocyte subsets in patients with acute coronary sydrome（ACS）. Methods： 88 cases of patients with ACS and 28 normal patients by angiography admitted from Mar 2013 to Mar 2014 in our hospital were studied.The changes in expression of CD4＋T cell subsets of Th1/Th2 and Th17/Treg ratio were detected by flow cytometry using blood collected during angiography of coronary artery. Results： Compared with the control group,the proportion of Th1 and Th17 cells in CD4＋T lymphocytes in coronary blood of patients with ACS significantly increased. While, the proportion of Th2 and Treg cells in CD4＋T lymphocytes significantly decreased（P0.05）. Conclusion： Immune response of ACS patients is enhanced, CD4＋T lymphocyte subsets with different functions are involved in the occurrence and development of atherosclerosis（AS）,Th1, Th17 can promote the progression of AS and instability, while Th1, Treg has the opposite effect.