脓毒症致凝血异常发生机制的研究进展

Research Progress on the Mechanism of Coagulopathy in Sepsis

脓毒症是由感染引起的全身炎症反应综合征,其病情凶险,死亡率高。凝血异常是脓毒症的主要特点之一,是多方面因素共同作用的结果。在脓毒症的发生发展过程中,炎症因子既可以激活凝血级联反应又可以抑制抗凝系统和纤维蛋白溶解系统,最终导致其凝血活性增强,炎症诱导的凝血紊乱进一步促进和加重炎症反应。而脓毒症患者的高凝状态可导致静脉血栓栓塞甚至DIC的发生,引起了研究者们的广泛关注。本文将就脓毒症致凝血异常发生机制的研究进展做一综述。

Sepsis is a systemic inflammatory response syndrome to presumed or known infection,which is an extensive clinical problem with high mortality. Disturbance of blood coagulation is one of the main characteristics of sepsis, which is the consequence of various affects together. In the development of sepsis, inflammatory cytokines both activate the coagulation cascade and inhibit anticoagulant mechanisms and fibrinolysis, which eventually results in the enhancement of procoagulant activity. Inflammation-induced coagulation further aggravate the inflammatory response. Hypercoagulability in sepsis may contribute to venous thromboembolism or disseminated intravascular coagulation（DIC）. This article is aimed to review the research progress on the mechanism of coagulopathy in sepsis.