Wnt信号通路与皮肤创面愈合的关系

The Relationship Between Wnt Signaling Pathway and Skin Wound Healing

创面愈合是由炎性细胞、细胞因子等多种因素共同参与,涉及组织修复、再生、重建的一个复杂有序的病理生理过程。皮肤慢性创面的愈合仍然是临床研究的重点与热点,随着分子生物学的发展,对皮肤创面愈合机制的认识也逐渐深入。Wnt信号通路是一条由Wnt蛋白及其受体、调节蛋白等组成的高度保守的信号通路,参与细胞增殖、凋亡、分化等多种生物学过程。Wnt信号通路作为参与皮肤愈合的信号通路之一,被认为具有调控皮肤及其附属器的发育、诱导皮肤附件的形态发生、调节毛囊的周期生长、促进创面血管新生及上皮重塑等多方面的功能。因此本文试从炎性细胞、成纤维细胞、干细胞、血管新生、表皮新生与毛囊新生等方面对Wnt信号通路与皮肤创面愈合的关系作一综述。

The healing of chronic skin wound, a complicated but orderly pathophysiolological process involved many factors such as inflammatory cell and cytokin and related to issue repair, regeneration and reconstruction, is still an important and hot spot in clinic research. With the development of molecular biology, we have a futher understanding about the mechanism of the wound healing.Wnt signaling pathway is a highly conserved pathway consisted of Wnt protein, receptor and regulatory protein, and participate in many process such as cell proliferation, apoptosis, differentiation. As a pathway involved in wound healing, Wnt signaling is considered to regulate and induce the development of skin, appendage and follicles, promote the angiogenesis of wound and epithelia remodeling. By reviewing the literature, we try to reveal the relationship between Wnt signaling pathway and skin wound healing from inflammatory cells, fibroblasts, stem cell, angiogenesis, epidermis and hair follicle regeneration and so on.