低分子肝素与普通肝素在介入手术中安全性与疗效的比较

Low Molecular Weight Heparin and Unfractionated Heparin in Percutaneous Coronary Intervention in the Comparative Safety and Efficacy

肝素已经普遍用于冠状动脉介入术中,但是由于在应用过程中抗凝效果个体差异大、出血风险相对较高、并发症等问题的日益显现,已经引起了医生们的注意。相对而言,低分子肝素具有抗凝作用强、出血风险低、并发症发生率相对较低、无需实验室监测等优点,进而越来越广泛的在冠状动脉介入术中担当重要角色。普通肝素与低分子肝素在冠状动脉介入术中的有效性与安全性的比较是值得我们去探讨的,知道普通肝素与低分子肝素的优缺点后,可使我们在冠状动脉介入术中更好的选择抗凝药物,使手术的成功率大大提高,降低术后并发症的发生,减轻患者的痛苦。本文结合普通肝素与低分子肝素的药理作用及相关临床研究的结果,分析比较了普通肝素与低分子肝素在冠状动脉介入术中的有效性与安全性。

Heparin has been widely used in coronary intervention, but because of the anticoagulant effect in the application process large individual differences, the relatively high risk of bleeding complications and other issues become more prominent, which has attracted the attention of doctors. In contrast, low molecular weight heparin anticoagulant effect, and bleeding risk is low, the relatively low incidence of complications, without laboratory monitoring, etc., tends to play an important role in the coronary intervention. Unffactionated heparin and low molecular weight heparin in percutaneous coronary intervention in the comparative efficacy and safety is worth to explore. Knowing the advantages and disadvantages of unfi＇actionated heparin and low molecular weight heparin, allows us to make better choice of anticoagulant drugs in coronary intervention, thus greatly improve the success rate of surgery to reduce the incidence of postoperative complications and to relieve the suffering of patients. In this paper, based on the pharmacological effects of unfractionated heparin and low molecular weight heparin and clinical results of the study, unfractionated heparin and low molecular weight heparin in percutaneous coronary intervention in efficacy and safety were analyzed and compared.