髓样细胞激发受体-2在中枢神经系统疾病中的研究进展

Progress of the triggering receptor expressed on myeloid cells-2 in central nervous system diseases

背景 髓样细胞激发受体（triggering receptor expressed by myeloid cells,TREM）是一种免疫球蛋白超家族受体,TREM-2在中枢神经系统（central nervous system,CNS）主要表达于小胶质细胞.研究发现TREM-2的激活可产生抑制小胶质细胞过度活化、减少促炎症因子分泌进而减轻CNS炎症损伤程度的作用.因此,TREM-2的激活可能产生神经保护作用.目的 探讨TREM-2在CNS疾病中的研究进展,通过减轻CNS炎症,进而为治疗CNS疾病提供新的治疗策略.内容 介绍TREM家族的特性,阐述TREM-2在不同CNS疾病中的功能,探讨其发挥作用的相关机制.趋向 TREM-2可能成为减轻CNS炎症反应的新靶点,为CNS疾病的治疗提供新的方向.

Background Triggering receptor expressed by myeloid cell （TREM） belongs to a kind of immunoglobulin superfamily.In the central nervous system,TREM-2 is mainly expressed in microglial cells.Some investigations indicated that the activation of TREM-2 could attenuate microglial activation,decrease the secretions of pro-inflammatory factors and attenuate the degree of neuroinflammation.Therefore activation of TREM-2 may induce a neuroprotective effect.Objective The aim of this review is to discuss the role of TREM-2 in the central nervous system （CNS） diseases for exploring a novel treatment by reducing neuroinflammation.Content At the beginning,the characteristics of the TREM family were introduced.And then the roles played by TREM-2 were discussed in many CNS diseases.Finally,we analyzed the potential mechanisms of TREM-2 in neuroprotections.Trend TREM-2 may become a novel therapeutic target for inhibiting inflammatory responses in CNS,which may provide a different direction for the treatments of CNS diseases.