Fe_3O_4-10-HCPT及Fe_3O_4-HCPT@SiO_2核壳纳米粒子的制备

Preparation of Fe_3O_4-10-HCPT and Fe_3O_4-HCPT@SiO_2 core-shell nanoparticles

为有效控制磁性四氧化三铁纳米粒子在水介质中的分散,防止其聚集.通过控制Na Cl溶液的物质的量浓度,对比研究磁性四氧化三铁纳米粒子在超声前和超声后在盐中的分散情况.实验结果表明,磁性四氧化三铁纳米粒子在0.4 mol/L的氯化钠中分散性最好,聚集度较小;进一步为了制备粒径均匀的复合磁性纳米载药粒子,通过调节10-羟基喜树碱溶液的p H,将10-羟基喜树碱和磁性纳米粒子制备成复合纳米粒子,并将其用二氧化硅包覆制备了复合载药纳米粒子,其复合纳米粒子的粒径大约为120 nm,结果显示通过该方法成功制备了理想的磁性纳米载药粒子.

To effectively control the dispersion and avoid the aggregate of Fe3O4 nanopartieles in the water, the dispersion of Fe3O4 nanoparticles was investigated before and after ultrasonic bath in different concentration of NaCl solution. The experimental results showed that the dispersion of Fe3O4 nanoparticles was little of aggeregates in the 0. 4 mol/L NaCl solution. Furthermore, the magnetic Fe3O4-10-Hydroxycamptothecin compounds were prepared by refining pH values of 10-Hydroxycamptothecin system, and then the Fe3O4-HCPT@ SiO2 core-shell structural nanoparticles were prepared, of which the diameter of the composite nanoparticle is about 120 nm. The drug release process proves the feasibility of this preparation method.