脑衰反应调节蛋白-2在细胞迁移和非神经系统相关疾病中的研究

Study of CRMP-2 in cell migration and non-nervous system-related diseases

脑衰反应调节蛋白-2(CRMP-2)是一种多功能调节蛋白,它不仅在哺乳类动物的神经系统内高度表达,而且在T细胞、肿瘤细胞和正常上皮细胞等非神经系统的细胞和组织中存在表达。在神经系统中,CRMP-2在促进神经轴突生长、维持神经细胞极性、神经元迁移等方面均起着重要作用。在非神经系统中,CRMP-2正向调节T细胞骨架重组和细胞迁移,负向调节肿瘤细胞的迁移水平,并以磷酸化形式参与肿瘤细胞增殖,被认为可能成为某些恶性肿瘤的生物标志物和治疗靶点。

Collapsin response mediator protein-2（ CRMP-2） is a multi-functional regulator protein.CRMP-2 is not only highly expressed in the mammalian nervous system,but also in non-neuronal cells and tissues,such as T lymphocytes,tumor cells and normal epithelial cells. In the nervous system,CRMP-2 plays an important role in promoting the outgrowth of neural axon,maintaining neural cell polarity and neuron migration.In the non-neuronal system,CRMP-2 positively regulates the cytoskeletal arrangement and cell migration of T lymphocytes,negatively interferes the cell migration of tumor cells and participates in tumor cell proliferation via phosphorylation. CRMP-2 is considered as a biomarker and therapeutic target of certain malignant tumors.