席夫碱的合成及生物活性

Synthesis and Biological Activity of Schiff Bases

以对溴苯酚和苯甲酰氯为原料,经过酯化、Fries重排、缩合等一系列反应,合成了2-[(2-苯基亚氨基)苯甲基]-4-溴苯酚,该化合物分别与多种醛酮在不同条件下反应,得到了5种不对称双席夫碱和2种对称性双席夫碱。对席夫碱化合物的抑菌活性测定表明,大部分化合物具有较强的抗菌活性,其中含硫原子的席夫碱抑菌活性最强,最小抑菌浓度均为1×10-4g/L。

With raw materials of benzoyl chloride and p-bromophenol, mono-Schiff base, 2-[ （2- aminophenylimino） phenylmethyl]-4-bromophenol, is obtained through multi-step reactions of esterification, Fries rearrangement and condensation. The mono-Schiff base reacts with aldehydes and ketones to give five asymmetric di-Schiff bases and two symmetric di-Schiff bases. These Schiff bases, particularly those containing sulfur atom in the molecule, show good antibacterial activities with a minimum inhibitory concentration of 1 × 10^-4g/L.