摘要
体细胞重编程是指用特定方法使已分化的细胞重新获得多能性的过程,可通过核移植、细胞融合、多能细胞提取物共培养和诱导性多能干细胞等途径实现。其中,诱导性多能干细胞技术发展最为迅速,应用前景广阔。现主要介绍重编程领域近年的研究进展。
Differentiated somatic cells can be reprogrammed to pluripotent state by several techniques, including nuclear transfer, cell fusion, co-culture with pluripotent cell extracts and the recently discovered induced pluripotent stem cell（i PSC） technology. i PSCs are highly valuable in regenerative medicine and the techniques in generating i PSCs are evolving very fast. In this review, we summarize recent progress in the research of somatic cell reprogramming and iPSCs.
出处
《生命科学》
CSCD
2015年第3期327-335,共9页
Chinese Bulletin of Life Sciences
基金
干细胞研究国家重大科学研究计划(2015CB964503)
中国科学院干细胞先导专项(XDA01040301)
国家自然科学基金项目(81425024
31371511)
关键词
体细胞重编程
诱导性多能干细胞
小分子化合物
转分化
somatic cell reprogramming
induced pluripotent stem cell
small molecules
trans-differentiation
