摘要在基础实验研究方面探讨Th17和调节性T细胞(regulatory T cells,Treg细胞)的生物学效应。Th17细胞表现为前炎性细胞亚类的特征,而Treg细胞具有拮抗Th17细胞的作用。Th17和Treg细胞的信号通路相互交通、制约,并可以转化,提示两种细胞间有一定的可塑性,也意味着Th17/Treg细胞的平衡在自身免疫病发展和结局中有重要作用。
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