糖尿病中医证型与实验室指标的相关性研究

Relationship between Type of Syndrome Differentiation and Laboratory Index in Type 2 Diabetes

目的探讨社区2型糖尿病患者的辨证分型与实验室指标的相关性,进一步探求对2型糖尿病中医辨证具有指导意义的实验室指标,为中医辨证由定性向定量诊断提供依据。方法检测786例东城区社区2型糖尿病患者的空腹血糖、谷丙转氨酶、总胆固醇、低密度脂蛋白、尿酸、肌酐等实验室指标,并运用二元Logistic回归检验探讨2型糖尿病中医证型与实验室指标的相关性。结果气阴两虚证患者最多为223例,占28.4%。胃肠热结证与空腹血糖有关(P<0.05,B=0.152),湿热困脾证与谷丙转氨酶(P<0.05,B=0.014)、血肌酐(P<0.05,B=-0.028)有关,肝经郁热证与尿酸有关(P<0.05,B=0.003)。结论气阴两虚证及阴虚津亏证是2型糖尿病患者的主要中医证型。中医证型与部分实验室指标之间有一定相关性。

Objective To study the relationship between type of syndrome differentiation of type 2 diabetes mellitus patients in com- munity and laboratory index, thus provide the basis for differentiation from the qualitative to the quantitative diagnosis of traditional Chi- nese medicine. Methods FBG, ALT, CHO, L - DLC, UA, Cr of 786 cases in dongcheng district community were tested to explore the relativity between syndrome differentiation of type 2 diabetes and laboratory index with binary logistic regression testing. Results The number of patients with Qi and Yin deficiency syndrome was 223,which was the most of all syndrome, accounting for 28.4%. Gastrointes- tinal hot junction syndrome was associated with fasting plasma glucose （P 〈 0. 05,B = 0. 152）, hot and humid trapped spleen syndrome and Alt （ P 〈 0.05, B = 0. 014 ） , serum creatinine （ P 〈 0.05, B = - 0. 028 ） , liver meridian muggy syndrome associated with uric acid （ P 〈 0.05 ,B = 0. 003）. Conclusion Qi and Yin deficiency syndrome and Yin deficient syndrome is still the main TCM syndrome types in patients with type 2 diabetes. There are some correlation between TCM syndrome types and some laboratory indexes.