摘要
通过硅胶、凝胶、RP-18和HPLC等一系列色谱方法对小芸木茎和叶中化学成分进行研究,得到8个化合物,包括两个新化合物（1、2）和6个已知化合物（3~8）。通过一维、二维核磁共振以及高分辨质谱等波谱数据对这些化合物进行结构鉴定,其中化合物microintegerrin C（1）为一个新的苯环衍生物,化合物microintegerrin D（2）为一个新的降倍半萜,化合物3~8为首次从该植物中分离得到。
A new benzene derivative microintegerrin C（1） and a new norsesquiterpenoid microintegerrin D（2）, along with six known compounds（3-8）, were isolated and identified from stems and leaves of Micromelum integerrimum by various chromatographies such as silica gel, Sephadex LH-20, RP-18 column chromatography and HPLC. Their structures were mainly identified based on the spectral data analysis such as 1D-, 2D-NMR and HR-EI-MS. All known compounds were isolated from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2015年第4期475-479,共5页
Acta Pharmaceutica Sinica
基金
Project supported by the National Natural Science Foundation of China(31470428,21202147,81001379)
National New Drug Innovation Major Project of China(2011ZX09307-002-02)
Natural Science Foundation of Yunnan Province(2012GA003)
