糖皮质激素致寻常型天疱疮患者功能失调性子宫出血1例

Patient with pemphigus vulgaris complicated with dysfunctional uterine bleeding upon glucocorticoid usage: a case report

天疱疮是一类严重的、慢性黏膜-皮肤大疱性自身免疫性疾病。临床治疗以系统应用糖皮质激素为主。功能失调性子宫出血是由下丘脑-垂体-卵巢轴功能失调引起的异常子宫出血。本文报道1例全身应用糖皮质激素后出现功能失调性子宫出血的寻常型天疱疮患者,并通过回顾文献对糖皮质激素导致功能失调性子宫出血的机制进行了探讨。

Pemphigus is a severe chronic autoimmune mucocutaneous bullous disease. Glucocorticoids are considered as the first line of treatment for this disease. Dysfunctional uterine bleeding is also observed as a result of hypothalamic-pituitary- ovary axis dysfunction. This study reported one female patient with pemphigns vulgaris complicated with dysfunctional uterine bleeding upon systemic glucocorticoid usage. Before this disease was diagnosed, the patient experienced normal menstruation. The mechanism of dysfunctional uterine bleeding triggered by glucocorticoids is elucidated on the basis of case studies and literature review.