摘要
Notch信号通路是一条在进化上高度保守、影响细胞命运的信号转导途径，可通过介导细胞间相互作用调控胚胎发育与组织更新，并参与肿瘤的发生和转移。近期研究发现该信号在骨形成过程中扮演重要的角色，对软骨细胞、成骨细胞和破骨细胞等的分化具有调节作用。其功能失调将导致多种骨发育和骨代谢疾病，并与骨肿瘤的发生密切相关。
Notch signaling is highly conserved in evolution and regarded as a key factor in cell fate determination. It mediates cell-to-cell interactions that are critical for embryonic development and tissue renewal, and is involved in the occurrence and metastasis of neoplasm. Recent researches have found that such signaling plays an important role in modulating the differentiation of chondrocytes, osteoblasts and osteoclasts. Dysfunction of Notch signaling can result in many skeletal diseases such as bone tumor, disorders of bone development or bone metabolism.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2015年第2期274-279,共6页
Chinese Journal of Medical Genetics
基金
国家自然科学基金（81270330,81270401,81300190）
陕西省科学技术研究发展计划项目（2013KJXX-89）
陕西省科学技术厅社发攻关项目（2014K11-02-03-02）
