不同体重指数的2型糖尿病腹腔镜胃旁路术后临床疗效对比研究

Clinical effect comparison of the type 2 diabetes mellitus with different BMI after the laparoscopic gastric bypass

目的探索体重指数(BMI)对糖尿病腹腔镜胃旁路术临床疗效的影响。方法从我院2010年至2013年实施腹腔镜胃旁路术的2型糖尿病患者中,随机从25 kg/m2<BMI<28 kg/m2、28 kg/m2≤BMI<35 kg/m2、35 kg/m2≤BMI各范围患者中抽出20例,共60例患者,相应作为低BMI组、中BMI组、高BMI组。统计分析3组患者术后12个月血糖控制率等指标差异。结果低BMI组、中BMI组、高BMI组血糖控制率分别为75%、85%、90%,3组患者血糖控制率比较无统计学差异,3组患者体质量、血糖术后12个月均较术前显著改善,空腹胰岛素、餐后2 h胰岛素也较术前降低。结论 3组不同BMI的2型糖尿病患者在腹腔镜胃旁路术后均获得了满意的临床疗效。

Objective To explore impact of BMI on the clinical efficacy of treatment of type 2 diabetes mellitus after the laparoscopic gastric bypass. Methods Twenty patients were randomly selected from type 2 diabetes mellitus patients with BMI of 25 ~ 28 kg / m2 after laparoscopic gastric bypass surgery in our hospital from 2010 to 2013,20 patients from type 2 diabetes mellitus patients with BMI of 28 ~ 35 kg / m2 and 20 patients from type 2 diabetes mellitus patients with BMI≥35 kg / m2. Accordingly,the total of 60 patients were divided into low BMI group,middle BMI group and high BMI group. The difference of the rate of blood glucose control and other indicators between three groups were compared and analyzed. Results The rate of blood glucose control in low BMI group was 75%,middle BMI group was 85%,and high BMI group was 90%. There was no statistical difference of the rate of blood glucose control between three groups at 12 months after laparoscopic gastric bypass surgery. The blood glucose and weight obviously improved in all patients,and fasting insulin and postprandial serum insulin decreased at 12 months after laparoscopic gastric bypass surgery. Conclusion All the patient of type 2 diabetes mellitus with different BMI in three group can acquire satisfying clinical therapeutic effect after the laparoscopic gastric bypass.