黛力新治疗伴焦虑抑郁情绪的非糜烂性胃食管反流病的临床观察

Clinical efficacy of Deanxit in non-erosive gastroesophageal reflux disease with anxiety and depression

目的：观察黛力新治疗伴焦虑抑郁的非糜烂性胃食管反流病的效果。方法经内镜及综合医院焦虑抑郁量表自测确定的伴焦虑抑郁的非糜烂性胃食管反流病（ NERD）76例，按随机数字表法分为对照组和黛力新治疗组，观察两组治疗1、4、8周后的临床疗效、症状和焦虑抑郁评分变化。结果黛力新能明显改善1周的总有效率（ P ＜0．01），提高1、4、8周的缓解率（1周：P ＜0．05；4周和8周：P ＜0．01）；改善1、4、8周的反流症状和焦虑抑郁评分（ P ＜0．01）。结论黛力新治疗伴焦虑抑郁的NERD，效果显著，起效快，缓解率高，能改善反流症状和焦虑抑郁。

Objective To investigate clinical effects of Deanxit in non-erosive gastroesophageal re-flux disease （ NERD） with anxiety and depression.Methods A total of 76 patients diagnosed NERD with anxiety and depression by endoscopy and hospital anxiety and depression scale （ HAD） were randomly divid-ed into regular treatment group and Deanxit treatment group.Clinical efficacy, symptom score, and anxiety and depression score were observed after one week, four weeks, and eight weeks.Results Deanxit signifi-cantly increased the clinical efficacy after one week （ P 〈0.01） and remission rate after one week （ P 〈0.05）, four and eight weeks （ P 〈0.01）.It improved symptoms, depression, and anxiety, which showed significant differences （ P 〈0.01） compared to control group after one week, four and eight weeks adminis-tration.Conclusions Deanxit can be applied in NERD with anxiety and depression treatment, which has quick effect and high remission rate, and improve patient＇s reflux symptoms and anxiety depression.