核因子E2相关因子2与细胞自噬对肝纤维化的影响

Roles of Nrf2 and autophagy in liver fibrosis

肝纤维化是慢性肝病发展到肝硬化的必经阶段,在全世界范围保持着较高的发病率。肝纤维化的发生机制复杂,其发生发展受到许多细胞因子及信号通路的影响,人们对肝纤维化的认识也越来越深入。简述了核因子E2相关因子2(Nrf2)介导的抗氧化应激系统在对抗各种类型肝纤维化中的作用和细胞自噬对肝纤维化的影响,以及Nrf2和自噬的相互影响在肝纤维化中可能的作用机制。认为将Nrf2和细胞自噬联合研究是未来肝纤维化发生机制的研究方向,为肝纤维化的治疗提供了新思路。

Liver fibrosis is an essential stage in the progression of chronic liver disease to liver cirrhosis,and its incidence is high in the world. The mechanism of liver fibrosis that involves many cytokines and signaling pathways is complicated and is understood by people more and more clearly. This review presents that nuclear factor- erythroid 2- related factor- 2（ Nrf2）- mediated antioxidant response plays a critical role in suppressing the progression of liver fibrosis. In addition,autophagy is also an important and complex regulator of liver fibrosis in different pathways. The possible mechanism of interaction between Nrf2 and autophagy in liver fibrosis is also described in this review.Currently,the research combining Nrf2 and autophagy is considered the future direction for the study of liver fibrosis,providing a new idea for the treatment of liver fibrosis.