多发性硬化的灰质病变
摘要
多发性硬化（ multiple sclerosis，MS ）是常见中枢神经系统疾病，以白质炎性脱髓鞘病灶、胶质瘢痕形成及轴索损伤为特点，被认为是针对髓磷脂抗原的自身免疫反应性疾病。自上世纪90年代即发现MS患者的灰质受到累及，随着病理及影像学技术的发展，MS灰质病变得到更充分的认识。现在认为灰质损害是MS的重要表现，是患者永久性功能残疾的关键因素。
出处
《脑与神经疾病杂志》
2015年第2期158-160,F0003,共4页
Journal of Brain and Nervous Diseases
基金
首都市民健康项目培育(Z131100006813020)
参考文献25
-
1Srinivasan R,Ratiney H,Hammond-Rosenbluth KE,et al.MR spectroscopic imaging of glutathione in the white and gray matter at 7T with an application to multiple sclerosis[J].Magn Reson Imaging,2010,28:163-170.
-
2Campbell GR,Ziabreva I,Reeve AK,et al.Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis[J].Ann Neurol,201,69:481-492.
-
3Zheng J,Bizzozero OA.Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis[J].J Neurochem,2011,117:143-153.
-
4Derfuss T,Parikh K,Velhin S,et al.Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals[J].Proc Natl Acad Sci USA,2009,106:8302-8307.
-
5Huizinga R,Gerritsen W,Heijmans N,et al.Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments[J].Neurobiol Dis,2008,32:461-470.
-
6Dinacci D,Tessitore A,Russo A,et al.BDNF Val66Met polymorphism and brain volumes in multiple sclerosis[J].Neurol Sci,2011,32:117-123.
-
7Albert M,Antel J,Bruck W,et al.Extensive cortical remyelination in patients with chronic multiple sclerosis[J].Brain Pathol,2007,17:129-138.
-
8Zhou F,Zee CS,Gong H,et al.Differential changes in deep and cortical gray matters of patients with multiple sclerosis:a quantitative magnetic resonance imaging study[J].J Comput Assist Tomogr,2010,34:431-436.
-
9Kidd D,Barkhof F,Mc Connell R,et al.Cortical lesions in multiple sclerosis[J].Brain,1999,122:17-26.
-
10Peterson JW,Bo L,Mork S,et al.Transected neurites,apoptotic neurons,and reduced inflammation in cortical multiple sclerosis lesions[J].Ann Neurol,2001,50:389-400.
-
1梁活,曾丽.小胶质细胞与多发性硬化[J].实用医学杂志,2010,26(5):873-875. 被引量：9
-
2钟晓南,胡学强.多发性硬化的研究进展[J].中华神经科杂志,2014,47(12):886-887. 被引量：4
-
3廖侠.脑卒中继发癫痫临床分析[J].中国现代医生,2009,47(15):230-231. 被引量：3
-
4李蜀渝,李刚.左旋咪唑致脱髓鞘脑病的临床及CT与MRI的比较研究[J].卒中与神经疾病,2000,7(3):167-169. 被引量：6
-
5孙辰婧,戚晓昆.多发性硬化灰质脱髓鞘临床病理研究进展[J].中华医学杂志,2012,92(43):3092-3094. 被引量：3
-
6来小音,桂梦翠,卜碧涛.重症肌无力相关抗体研究进展[J].中华神经科杂志,2013,46(9):629-633. 被引量：5
-
7陈璇,李咏梅.多发性硬化灰质病变多模态MRI研究进展[J].中国医学影像技术,2010,26(10):1990-1992. 被引量：2
-
8林锦霞,易冬娟,洪锦治.重症肌无力危象患者的护理[J].福建医药杂志,2006,28(5):171-172.
-
9刘辉,曲方.多发性硬化灰质病变研究进展[J].国际神经病学神经外科学杂志,2011,38(5):471-474. 被引量：2
-
10林志忠,田进军,张和平.外伤后脑桥中央髓鞘溶解症3例并文献复习[J].中国实用医药,2010,5(10):163-164. 被引量：1
