持久性有机污染物与糖尿病发病相关分子机理

Molecular Mechanisms Related to Persistent Organic Pollutants Induced Diabetes

持久性有机污染物(persistent organic pollutants,POPs)是一类理化性质稳定、难降解、高脂溶性、高蓄积性的环境污染物。越来越多的研究表明,POPs与糖尿病发病密切相关,但涉及的分子机理较为复杂。该文综述了国内外近年关于POPs引起1型和2型糖尿病发病的分子机理,旨在讨论POPs与两种糖尿病发病的内在联系。

Persistent organic pollutants（POPs） belong to environmental chemicals with properties such as stabilization, degradation-resistant, high lipid solubility and high accumulation. More and more studies have shown that POPs were closely associated with diabetes and the related molecular mechanisms were complex. The present review discussed the molecular mechanism about type 1 and type 2 diabetes induced by POPs. The purpose of this review was to illuminate the internal relation of POPs and two types of diabetes.