尼麦角林联合高压氧治疗血管性认知功能障碍疗效观察

Efficacy of nicergline combined with hyperbaric oxygen treatment on vascular cognitive impairment

目的 探讨尼麦角林联合高压氧治疗血管性认知功能障碍（VCI）的疗效.方法 选取血管性认知功能障碍患者120例,随机分为尼麦角林治疗组40例,高压氧治疗组40例,联合治疗组40例,疗程共8周,以简易精神状态检查表（MMSE）、韦克斯勒记忆量表（WMS）和日常生活能力量表（ADL）为评价指标,评价3组患者的疗效.结果 3组患者临床资料比较差异无统计学意义（均P＞0.05）,具有可比性.经8周治疗干预后,联合治疗组MMSE、WMS、ADL较治疗前均有改善（P＜0.01）.尼麦角林治疗组上述三项指标改善明显（P＜0.05）,而高压氧治疗组MMSE、ADL评分较前改善（P＜0.05）,联合治疗组与尼麦角林治疗组和高压氧治疗组组间比较,上述指标差异有统计学意义（P＜0.05）.而尼麦角林组与高压氧治疗组比较,仅MMSE差异有统计学意义.3组均无明显相关不良反应出现.结论 在血管性认知功能障碍治疗中,尼麦角林联合高压氧治疗疗效显著,患者日常生活能力和认知能力提高明显,无不良反应发生,值得在临床中推广.

Objective To investigate the efficacy of nicergoline combined with hyperbaric oxygen treatment on vascular cognitive impairment.Methods 120 patients with vascular cognitive impairment were randomly divided into 3 treatment groups：nicergoline,hyperbaric oxygen,and both treatment （n=40,each） for 8 weeks.Mini mental state examination （MMSE）,Wechsler memory scale （WMS） and activities of daily living scale （ADL） were used as assessing items.The efficacy of treatment in each group was evaluated.Results There were no significant differences in clinical data among the three groups（χ2=0.324,t=0.265 and 0.861,P=0.764,0.784 and 0.386）.After 8 weeks of intervention,scores of MMSE,WMS and ADL were significantly improved in the combined treatment groups compared with pre-treatment （all P〈0.01）,and the improvements were observed in nicergoline group （all P〈0.05）,while only MMSE and ADL were improved in hyperbaric oxygen group （both P〈0.05）.There were significant differences in scores of MMSE,WMS and ADL between combination therapy group and nicergoline group,hyperbaric oxygen group after treatment （all P〈0.05）.But only MMSE had significant difference between niccrgoline group and hyperbaric oxygen group after treatment.No significant side effects were observed in the three groups.Conclusions Combination treatment of nicergline and hyperbaric oxygen has better efficacy on vascular cognitive impairment.It can markedly improve the activities of daily living and cognitive function without significant side effects,which is worthy of application in clinical medicine.