慢性肾脏病之“浊邪”探讨

Discussion of “Turbid Pathogen”in Chronic Kidney Disease

在慢性肾脏病中,"浊邪"主要指浊阴之类,具有流动性、污秽性和有害性,如饮、水、痰、湿以及部分瘀血(血行缓慢之瘀血),可称水浊、痰浊、湿浊、饮浊、瘀浊。当多种并存时,常常概称为"浊邪"。对于"浊邪"的发病机制,现代医学对其的研究仍处于动物实验阶段,缺乏较为系统的认识及根本性治疗措施。中药复方在治疗慢性肾脏病脂质代谢紊乱具有多靶点、多向性、多层面等优势,且副作用较小,价格较低,但中药药物间的协同降脂效应及单味药有效降脂成分、作用机理研究尚待完善。

In chronic kidney disease,turbid pathogen is both the pathogenic factor and pathological production.It belongs to the turbid yin with the features of liquidity,dirtiness and harmfulness.For example,fluid,water,phlegm,damp and some blood stasis（stasis due to slow blood flow） can be called as water turbidity,phlegm turbidity,damp turbidity,fluid turbidity and turbidity of blood stasis.The multiple coexistence of the above can be generalized as＂turbid pathogen＂.For the pathogenesis of＂turbid pathogen＂,the research by modern medicine is still at the stage of animal experiment and lacks relative systematic understanding and radical treatment measures.Compound Chinese patent medicine has advantages of multi-targets,multi-direction,multi-level,little side effects,and low price in treating lipid metabolism disorder in kidney disease.However,the collaborative lipid-lowering effect,the effective lipid-lowering components and action mechanism remain to be improved.