围绝经女性糖尿病微血管病变与血脂异常的相关性研究

RELATIONSHIPS BETWEEN DYSLIPIDEMIA AND DIABETIC MICROANGIOPATHY IN PERIMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS

目的:探讨血脂异常与围绝经期女性糖尿病微血管病变发生的相关性。方法:围绝经期女性2型糖尿病患者120例,依据有无糖尿病微血管病变分为病例组和对照组,每组60例。分别检测两组的血脂、血压、空腹血糖(FBG)和糖化血红蛋白(Hb A1C)等指标。结果:病例组患者的病程、FBG、低密度脂蛋白胆固醇(LDL-C)、Hb A1C、收缩压明显高于对照组,高密度脂蛋白胆固醇明显低于对照组(P<0.05);两组年龄、甘油三酯、总胆固醇、体重指数、舒张压比较差异无统计学意义(P>0.05)。Logistic回归分析显示,病程、FBG、LDL-C、Hb A1C是糖尿病微血管病变的独立危险因素。结论:LDL-C升高和高血糖与围绝经期女性2型糖尿病微血管病变的发生密切相关。

Objective： To investigate the relationships between dyslipidemia and diabetic microangiopathy in perimenopausal women with type 2 diabetes mellitus.Methods： 120 perimenopausal women with type 2 diabetes mellitus were divided into case group（60 cases） and control group（60 cases） according to diabetic microangiopathy. The blood lipid, blood pressure, fasting blood-glucose（FBG） and glycosylated hemoglobin（Hb A1C） were respectively detected. Results：The course of disease, FBG, low density lipoprotein cholesterin（LDL-C）, Hb A1 C and systolic blood pressure of patients in case group were obviously higher than that of patients in control group（P〈0.05）; high density lipoprotein cholesterin was obviously lower（P〈0.05）. There had no statistical signif icance between age, triglyceride, total cholesterol, body mass index and diastolic blood pressure of patients in case group and control group（P〉0.05）. Logistic regression analyses showed that course of disease, FBG, LDL-C, and HbA 1C are independent risk factors of diabetic microangiopathy. Conclusions： High LDL-C and hyperglycemia are closely related to diabetic microangiopathy in perimenopausal women with type 2 diabetes mellitus.