性激素和精神分裂症精神病理的相关性研究

Study of correlation between sex hormone and psychopathology in schizophrenic patients

目的探讨性激素和精神分裂症精神病理性别差异的相关性。方法将60例女性、20例男性精神分裂症患者,于治疗前进行阳性和阴性综合征量表(PANSS)评定以及雌二醇(E2)、睾酮(T)、催乳素(PRL)、促卵泡激素(FSH)、黄体生成素(LH)的检测并与20名(男女各10名)正常人对照。结果男性患者E2、T水平均低于对照组(P<0.01),女性患者E2水平低于对照组(P<0.01)。女性患者PANSS阳性症状评分高于男性患者(P=0.008),阴性症状评分低于男性患者(P=0.001)。女性患者的E2水平与阴性症状评分呈负相关(P=0.020),而男性患者的E2及T水平均与阴性症状评分呈负相关(P=0.010,P=0.049)。结论精神分裂症患者在精神病理上存在性别差异,而这种差异与雌激素、睾酮存在相关性。

Objective To explore the correlation between serum level of sex hormones and gender difference in psychopathology in schizophrenia.Methods The serum level of estradiol （E2）,testosterone （T）,prolactin （PRL）,follicle-stimulating hormone （FSH）and luteinizing hormone （LH）were measured in 80 treatment-nave schizophrenic patients （study group,60 females and 20 males）and 20 healthy controls （control group,10 females and 10 males）.All subjects in study group were assessed with Positive and Negative Syndrome Scale （PANSS）before treatment.Results Serum levels of E2 and T in male schizophrenic patients were significantly lower than those in control group （P 〈0.01）,and serum level of E2 in female patients was significantly lower than that in control group （P 〈0.01）.Factor score of positive symptoms （P）of PANSS in female patients was significantly higher than that in male patients （P =0.008）,while factor score of negative symptoms in female patients was significantly lower than that in male patients （P =0.001 ）.Serum level of E2 in female patients was significantly negatively correlated with factor score of N （P =0.020）.However,serum levels of E2 and T in male patients were significantly negatively correlated with factor score of N （P =0.010,0.049 respectively）.Conclusion Gender difference exists in the psychopathology of schizophrenia and it may be related with estradiol and testosterone.