肿瘤标志物检测对癌性和结核性胸腔积液的鉴别诊断价值

Clinical value of differential diagnosis of tumor markers detection for cancerous and tuberculous pleural effusion

目的探讨肿瘤标志物检测对癌性、结核性胸腔积液鉴别诊断的临床价值。方法收集2013年5月至2014年4月间收治的110例胸腔积液患者的临床资料,其中癌性组52例,结核性组58例,对两组患者的癌胚抗原(CEA)、糖类抗原(CA199、CA153)测定结果进行比较。结果癌性组患者血清及胸腔积液中CEA、CA199、CA153水平明显高于结核性组患者,差异均有统计学意义(P<0.05)。联合检测CEA、CA199、CA153对恶性胸腔积液的敏感度均明显高于单独检测CEA和糖类抗原CA199、CA153,差异有统计学意义(P<0.05)。结论肿瘤标志物CEA、CA199、CA153对癌性、结核性胸腔积液具有鉴别诊断价值,且两者联合检测能够明显提高癌性胸腔积液的诊断敏感度。

Objective To investigate the clinical value of differential diagnosis of tumor markers detection for cancerous and tuberculous pleural effusion. Methods From May 2013 to April 2014,110 cases with pleural effusion in The Fourth Hospital of Tangshan City were enrolled in the study. And they were randomly divided into two groups according to the characteristic of pleural effusion,52 cases with cancerous pleural effusion and 58 cases with tuberculous pleural effusion. Carcinoembryonic antigen（ CEA）,carbohydrate antigen（ CA199,CA153） of the two groups were compared and analyzed. Results The serum and pleural effusion CEA,CA199,CA153 levels of the cancerous group were significantly higher than those in the tuberculous group,and there were significant differences between two groups（ P〈0. 05）; The sensitivity of CEA and CA199,CA153 combined detection of cancerous pleural effusion were significantly higher than CEA or carbohydrate antigen alone detection,and the difference was statistically significant between two groups（ P〈0. 05）. Conclusion CEA,CA199,CA153 of tumor markers for cancerous and tuberculous pleural effusion have differential diagnosis value,and combined detection can significantly improve the diagnosis sensitivity of cancerous pleural effusion.