癌胚抗原125与附睾蛋白4联合检测在子宫病变中的诊断意义

Diagnosis significance of cancer antigen 125 combined with epididymis protein 4 for endometriosis

目的探讨癌胚抗原125(CA125)与附睾蛋白4(HE4)联合检测子宫病变的临床意义。方法选择2012年8月至2014年8月间收治的49例子宫内膜异位症患者、63例卵巢良性肿瘤患者、44例卵巢恶性病变患者作为研究对象,通过化学发光免疫法、酶联免疫法检测并比较各组血清CA125和HE4水平。结果子宫内膜异位症患者血清CA125、HE4水平与卵巢良性肿瘤患者和卵巢恶性病变患者相比,差异均有统计学意义(均P<0.05)。与单项检测相比,CA125与HE4联合检测子宫内膜异位症的敏感度明显提高,差异有统计学意义(P<0.05)。结论 CA125与HE4联合检测子宫内膜异位症的敏感度高,具有重要的临床诊断意义。

Objective The aim of this study is to explore the diagnosis significance of cancer antigen 125（ CA125） combined with epididymis protein 4（ HE4） for endometriosis. Methods From August2012 to August 2014,49 cases of endometriosis,63 cases of benign ovarian tumor and 44 cases of ovarian malignant lesions accepting treatment in Traditional Chinese Medicine Hospital of Guangyuan were enrolled in the study. The CA125 and HE4 were detected by chemical method optical immunoassay and enzymelinked immunosorbent assay. Results Compared with the serum levels of CA125 and HE4 between the patients with endometriosis,benign ovarian tumor and ovarian malignant lesions,the differences were statistical significance（ P〈0. 05）; compared with the single detection,the detection sensitivity of CA125 combined with HE4 in the diagnosis of endometriosis were significantly increased,with statistical difference（ P〈0. 05）. Conclusion The detection of CA125 combined with HE4 has the high sensitivity for endometriosis and play the important clinical diagnosis significance.