人类白细胞抗原与肿瘤相关性的研究进展

Research progress of the relevance between tumor and human leukocyte antigen

人类白细胞抗原（HLA）在基因水平具有高度多态性,是参与机体免疫反应的重要分子,其表达缺失或过多都将导致免疫反应异常.肿瘤逃逸机体的免疫杀伤,这成为肿瘤发生、发展的可能机制.深入研究HLA表达异常与肿瘤的关系,可对肿瘤发生机制的研究和肿瘤免疫治疗提供重要的帮助.

Human leukocyte antigen （HLA） has high polymorphism at the genetic level,which is one of the important molecules in human immune response,lack-or over-expression will lead to abnormal immune response.The escape ot tumor from the immune damage is a possible mechanism of tumor occurrence and development.Further study about the relationship between abnormal expression of HLA and the tumor may provide important evidence on the study of mechanism of tumorigenesis and tumor immunotherapy.