摘要
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic (DA) neurons and a decrease in striatal dopamine, which is associated with clinical movement disorders including a tremor at rest, rigidity of the limbs, bra- dykinesia (slowness and paucity of voluntary movement) and postural instability (a tendency to fall even in the absence of weakness or cerebellar balance disturbance) (Kim et al., 2012). Although the lack of fully understanding of the etiology of PD, accumulating evidence suggests that microglial activation (Kim et al., 2010) and insufficient support of neurotrophic factors (Kim et al., 2012; Nam et al., 2014) may be crucial for the ini- tiation and progression of PD. Thus the control of microglial activation and the support of neurotrophic factors may be useful to prevent the degeneration of the nigrostriatal DA pro- jections in the adult brain.
Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic (DA) neurons and a decrease in striatal dopamine, which is associated with clinical movement disorders including a tremor at rest, rigidity of the limbs, bra- dykinesia (slowness and paucity of voluntary movement) and postural instability (a tendency to fall even in the absence of weakness or cerebellar balance disturbance) (Kim et al., 2012). Although the lack of fully understanding of the etiology of PD, accumulating evidence suggests that microglial activation (Kim et al., 2010) and insufficient support of neurotrophic factors (Kim et al., 2012; Nam et al., 2014) may be crucial for the ini- tiation and progression of PD. Thus the control of microglial activation and the support of neurotrophic factors may be useful to prevent the degeneration of the nigrostriatal DA pro- jections in the adult brain.