摘要
The human brain is known to contain a maximum of eight cholinergic nuclei: the basal forebrain region: the medial septal nucleus (Ch 1), the vertical nucleus of the diagonal band (Ch 2), the horizontal limb of the diago- nal band (Ch 3), and the nucleus basalis of Meynert (Ch 4); the brainstem: the pedunculopontine nucleus (Ch 5), the laterodorsal tegmental nucleus (Ch 6), and the para- bigeminal nucleus (Ch 8); and the thalamus: the medial habenular nucleus (Ch 7) (Nieuwenhuys et al., 2008; Naidich and Duvernoy, 2009). The cingulum is the neu- ral tract extending from the orbitofrontal cortex to the medial temporal lobe (Mufson and Pandya, 1984). The cingulum plays an important role in memory because it is a passage of the medial cholinergic pathway, which pro- vides cholinergic innervations to the cerebral cortex after originating from Ch 1 and Ch 2 as well as Ch 4 (mainly) (Selden et al., 1998; Nieuwenhuys et al., 2008; Hong and lang, 2010).
The human brain is known to contain a maximum of eight cholinergic nuclei: the basal forebrain region: the medial septal nucleus (Ch 1), the vertical nucleus of the diagonal band (Ch 2), the horizontal limb of the diago- nal band (Ch 3), and the nucleus basalis of Meynert (Ch 4); the brainstem: the pedunculopontine nucleus (Ch 5), the laterodorsal tegmental nucleus (Ch 6), and the para- bigeminal nucleus (Ch 8); and the thalamus: the medial habenular nucleus (Ch 7) (Nieuwenhuys et al., 2008; Naidich and Duvernoy, 2009). The cingulum is the neu- ral tract extending from the orbitofrontal cortex to the medial temporal lobe (Mufson and Pandya, 1984). The cingulum plays an important role in memory because it is a passage of the medial cholinergic pathway, which pro- vides cholinergic innervations to the cerebral cortex after originating from Ch 1 and Ch 2 as well as Ch 4 (mainly) (Selden et al., 1998; Nieuwenhuys et al., 2008; Hong and lang, 2010).
基金
supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)
funded by the Ministry of Education,Science and Technology,No.2012R1A1A4A01001873