肌肉特异性microRNA-206:研究现状及前景

Muscle-specific microRNA-206: research status and prospects

背景:骨骼肌占了人体总体质量的40%,然而许多骨骼肌损伤和疾病的机制问题尚未解决。MicroRNA-206(miR-206)是骨骼肌特异性miRNA,在骨骼肌的发育和再生中起着重要的作用。目的:总结分析microRNA-206在骨骼肌损伤和疾病中的研究现状。方法:以"miR-206,skeletal muscle"为检索词,计算机检索1992至2014年PubMed数据库相关文献的全文,经过筛选最终对60篇miR-206在骨骼肌损伤和疾病中的相关研究进行分析讨论。结果与结论:MiR-206能调节神经肌肉损伤后神经肌肉接点的恢复。相关研究显示,控制miR-206水平可能成为治疗肌萎缩侧索硬化症等肌肉疾病的新方法。通过细胞培养发现miR-206能促进卫星细胞的分化,缺乏miR-206会导致卫星细胞延迟分化,在骨骼肌损伤中也发现mi R-206能促进骨骼肌的再生。miR-206长期运动适应后水平下降,但当运动适应停训一段时间后,miR-206会恢复到原先的水平,而其机制还有待研究。

BACKGROUND：Skeletal muscle accounts for 40%of total body weight, but mechanisms of many skeletal muscle injuries and diseases have not been resolved. MicroRNA-206 （miR-206） is a skeletal muscle-specific microRNA, which plays an important role in skeletal muscle development and regeneration. OBJECTIVE：To analyze the research status of miR-206 in skeletal muscle injuries and diseases. METHODS：A computer-based search of PubMed was performed for articles about microRNA-206 in skeletal muscle injuries and diseases published from 1992 to 2014 using the keywords of“miR-206, skeletal muscle”. Final y, 57 articles were included in result analysis. RESULTS AND CONCLUSION：miR-206 can regulate neuromuscular junction recovery after nerve muscle injury. Studies have shown that to control miR-206 levels may be a new method for the treatment of amyotrophic lateral sclerosis and other muscle diseases. miR-206 can promote the differentiation of satel ite cel s in cel culture, and the lack of miR-206 can delay the differentiation of satel ite cel s. miR-206 is also found to promote the regeneration of skeletal muscle. After long-term exercise, the miR-206 level shows an adaptive decrease, but if the exercise is stopped for some time, the miR-206 level can return to its original level. Its mechanism remains to be studied.