COPD急性加重期并发CPHD心力衰竭患者血BNP和内脂素水平的临床意义

Significance of serum BNP and visfatin level in patients with acute exacerbation of chronic obstruction pulmonary disease complicated with chronic pulmonary heart disease and heart failure

目的探讨慢性阻塞性肺病(COPD)急性加重期并发慢性肺源性心脏病(CPHD)心力衰竭时血B型脑钠肽(BNP)及内脂素变化的意义。方法选择COPD急性加重期并发CPHD心力衰竭患者75例,健康体检者50例,根据NYHA心功能分级方法对患者进行分组,检测及比较各组的BNP和内脂素及其与血氧分压(PaO_2)之间的关系。结果COPD急性加重期并发CPHD患者组BNP和内脂素水平显著高于健康体检者(P<0.05),随心功能分级增加BNP和内脂素水平而逐渐升高、PaO_2水平逐步下降,PaO_2与BNP和内脂素水平呈负相关(r=-0.381,-0.295,均P<0.05),BNP和内脂素呈正相关(r=0.361,P<0.05)。结论 COPD急性加重期并发CPHD心力衰竭患者BNP和内脂素水平明显升高,与缺氧有关。

Objective To investigate significance of serum BNP and visfatin level in patients with acute exacerbation of chronic obstruction pulmonary disease （COPD） complicated with chronic pulmonary heart disease （CPHD） and heart failure （HF）. Methods 75 patients with acute exacerbation of COPD complicated with CPHD and HF and 50 healthy people were enrol ed. The patients were grouped according to New York Heart Association （NYHA） classification.Serum BNP and visfatin concentrations were measured and compared between groups and their relation to PaO2 was determined. Results The serum BNP and visfatin were significantly higher in the patients with acute exacerbation of COPD and CPHD than in healthy people （P〈0.05）.The serum BNP and visfatin level increased and PaO2 decreased gradual y as NYHA class increased.PaO2 was negatively correlated with serum BNP and visfatin （r= - 0.381, - 0.295, P〈0.05）.BNP was positively correlated with visfatin（r=0.361, P〈0.05）. Conclusion Serum BNP and visfatin increase obviously in patients with acute exacerbation of COPD complicated with CPHD and HF, which are correlated with hypoxia.